The Role of ADAM17 in PCOS Pathogenesis: A review Paper
DOI:
https://doi.org/10.59653/jhsmt.v2i02.632Keywords:
PCOS, ADAM17, PathogenesisAbstract
This review primarily focuses on the Role of metalloproteinase (ADAM 17). Gynecological disease contributes to approximately 4.5% of the worldwide disease burden. Gynecological problems in women of reproductive age are linked to both In terms of diagnosis and treatment. Because there are no defined biomarkers, identifying gynecological disorders, particularly malignancies, has been difficult in most cases, and histopathological exams remained the gold benchmark. M.M.P.s, ADAMs, and ADAMTSs, as well as their endogenous inhibitors (TIMPs), influence the protease-dependent bioavailability of local niche components. ADAM 17 has been implicated in various pathological processes, including inflammatory response, cardiovascular disease, and, recently, ovarian dysfunction. Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age and is characterized by chronic anovulation, insulin resistance, and increased prevalence of cardiovascular risk factors. So far, the PCOS has not assessed the circulating levels of MMPs and their tissue inhibitors (TIMPs). This review will concentrate on the Role of (ADAM17) in regulating gynecological disorder (PCOS) and their consequent modulation for therapeutic intervention.
Downloads
References
Adamcova, M., Kawano, I., & Simko, F. (2021). The impact of micrornas in renin–angiotensin-system-induced cardiac remodelling. In International Journal of Molecular Sciences (Vol. 22, Issue 9). https://doi.org/10.3390/ijms22094762
Ciebiera, M., Włodarczyk, M., Zgliczyńska, M., Łukaszuk, K., Męczekalski, B., Kobierzycki, C., Łoziński, T., & Jakiel, G. (2018). The role of tumor necrosis factor α in the biology of uterine fibroids and the related symptoms. In International Journal of Molecular Sciences (Vol. 19, Issue 12). https://doi.org/10.3390/ijms19123869
Ciumărnean, L., Milaciu, M. V., Negrean, V., Orășan, O. H., Vesa, S. C., Sălăgean, O., Iluţ, S., & Vlaicu, S. I. (2022). Cardiovascular risk factors and physical activity for the prevention of cardiovascular diseases in the elderly. In International Journal of Environmental Research and Public Health (Vol. 19, Issue 1). https://doi.org/10.3390/ijerph19010207
Deswal, R., Narwal, V., Dang, A., & Pundir, C. S. (2020). The Prevalence of Polycystic Ovary Syndrome: A Brief Systematic Review. In Journal of Human Reproductive Sciences (Vol. 13, Issue 4). https://doi.org/10.4103/jhrs.JHRS_95_18
Dou, H., Feher, A., Davila, A. C., Romero, M. J., Patel, V. S., Kamath, V. M., Gooz, M. B., Rudic, R. D., Lucas, R., Fulton, D. J., Weintraub, N. L., & Bagi, Z. (2017). Role of Adipose Tissue Endothelial ADAM17 in Age-Related Coronary Microvascular Dysfunction. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(6). https://doi.org/10.1161/ATVBAHA.117.309430
Düsterhöft, S., Babendreyer, A., Giese, A. A., Flasshove, C., & Ludwig, A. (2019). Status update on iRhom and ADAM17: It’s still complicated. In Biochimica et Biophysica Acta - Molecular Cell Research (Vol. 1866, Issue 10). https://doi.org/10.1016/j.bbamcr.2019.06.017
Düsterhöft, S., Lokau, J., & Garbers, C. (2019). The metalloprotease ADAM17 in inflammation and cancer. In Pathology Research and Practice (Vol. 215, Issue 6). https://doi.org/10.1016/j.prp.2019.04.002
Escobar-Morreale, H. F. (2018). Polycystic ovary syndrome: Definition, aetiology, diagnosis and treatment. In Nature Reviews Endocrinology (Vol. 14, Issue 5). https://doi.org/10.1038/nrendo.2018.24
Floyd, R., Gryson, R., Mockler, D., Gibney, J., Duggan, S. N., & Behan, L. A. (2022). The Effect of Time-Restricted Eating on Insulin Levels and Insulin Sensitivity in Patients with Polycystic Ovarian Syndrome: A Systematic Review. In International Journal of Endocrinology (Vol. 2022). https://doi.org/10.1155/2022/2830545
Freeman, E. W., Kroll, R., Rapkin, A., Pearlstein, T., Brown, C., Parsey, K., Zhang, P., Patel, H., & Foegh, M. (2001). Evaluation of a unique oral contraceptive in the treatment of premenstrual dysphoric disorder. Journal of Women’s Health and Gender-Based Medicine, 10(6). https://doi.org/10.1089/15246090152543148
Gheblawi, M., Wang, K., Viveiros, A., Nguyen, Q., Zhong, J. C., Turner, A. J., Raizada, M. K., Grant, M. B., & Oudit, G. Y. (2020). Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2. In Circulation Research (Vol. 126, Issue 10). https://doi.org/10.1161/CIRCRESAHA.120.317015
Giménez-Palomo, A., Gomes-da-Costa, S., Dodd, S., Pachiarotti, I., Verdolini, N., Vieta, E., & Berk, M. (2022). Does metabolic syndrome or its component factors alter the course of bipolar disorder? A systematic review. In Neuroscience and Biobehavioral Reviews (Vol. 132). https://doi.org/10.1016/j.neubiorev.2021.11.026
Grieve, A. G., Xu, H., Künzel, U., Bambrough, P., Sieber, B., & Freeman, M. (2017). Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling. ELife, 6. https://doi.org/10.7554/eLife.23968
Hajam, Y. A., Rani, R., Ganie, S. Y., Sheikh, T. A., Javaid, D., Qadri, S. S., Pramodh, S., Alsulimani, A., Alkhanani, M. F., Harakeh, S., Hussain, A., Haque, S., & Reshi, M. S. (2022). Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives. Cells, 11(3). https://doi.org/10.3390/cells11030552
He, F. F., & Li, Y. M. (2020). Role of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome: A review. In Journal of Ovarian Research (Vol. 13, Issue 1). https://doi.org/10.1186/s13048-020-00670-3
Huffman, A. M., Rezq, S., Basnet, J., Cardozo, L. L. Y., & Romero, D. G. (2021). Sars-cov-2 viral entry proteins in hyperandrogenemic female mice: implications for women with pcos and covid-19. International Journal of Molecular Sciences, 22(9). https://doi.org/10.3390/ijms22094472
Imanaka, S., Maruyama, S., Kimura, M., Nagayasu, M., & Kobayashi, H. (2020). Towards an understanding of the molecular mechanisms of endometriosis-associated symptoms (Review). In World Academy of Sciences Journal (Vol. 2, Issue 4). https://doi.org/10.3892/wasj.2020.53
Ipsa, E., Cruzat, V. F., Kagize, J. N., Yovich, J. L., & Keane, K. N. (2019). Growth Hormone and Insulin-Like Growth Factor Action in Reproductive Tissues. In Frontiers in Endocrinology (Vol. 10). https://doi.org/10.3389/fendo.2019.00777
Islam, R. M., Bell, R. J., Green, S., Page, M. J., & Davis, S. R. (2019). Safety and efficacy of testosterone for women: a systematic review and meta-analysis of randomised controlled trial data. The Lancet Diabetes and Endocrinology, 7(10). https://doi.org/10.1016/S2213-8587(19)30189-5
Jung, Y. J., Tweedie, D., Scerba, M. T., & Greig, N. H. (2019). Neuroinflammation as a Factor of Neurodegenerative Disease: Thalidomide Analogs as Treatments. In Frontiers in Cell and Developmental Biology (Vol. 7). https://doi.org/10.3389/fcell.2019.00313
Kakoly, N. S., Earnest, A., Teede, H. J., Moran, L. J., & Joham, A. E. (2019). The impact of obesity on the incidence of type 2 diabetes among women with polycystic ovary syndrome. Diabetes Care, 42(4). https://doi.org/10.2337/dc18-1738
Kawai, T., Elliott, K. J., Scalia, R., & Eguchi, S. (2021). Contribution of ADAM17 and related ADAMs in cardiovascular diseases. In Cellular and Molecular Life Sciences (Vol. 78, Issue 9). https://doi.org/10.1007/s00018-021-03779-w
Kostopoulou, E., Anagnostis, P., Bosdou, J. K., Spiliotis, B. E., & Goulis, D. G. (2020). Polycystic ovary Syndrome in Adolescents: Pitfalls in Diagnosis and Management. In Current obesity reports (Vol. 9, Issue 3). https://doi.org/10.1007/s13679-020-00388-9
Kshetrimayum, C., Sharma, A., Mishra, V. V., & Kumar, S. (2019). Polycystic ovarian syndrome: Environmental/ occupational, lifestyle factors; an overview. In Journal of the Turkish German Gynecology Association (Vol. 20, Issue 4). https://doi.org/10.4274/jtgga.galenos.2019.2018.0142
Kunvariya, A. D., Dave, S. A., Modi, Z. J., Patel, P. K., & Sagar, S. R. (2023). Exploration of multifaceted molecular mechanism of angiotensin-converting enzyme 2 (ACE2) in pathogenesis of various diseases. In Heliyon (Vol. 9, Issue 5). https://doi.org/10.1016/j.heliyon.2023.e15644
Lai, W., Li, X., Zhu, H., Zhu, X., Tan, H., Feng, P., Chen, L., & Luo, C. (2020). Plasma luteinizing hormone level affects the brain activity of patients with polycystic ovary syndrome. Psychoneuroendocrinology, 112. https://doi.org/10.1016/j.psyneuen.2019.104535
Light, R. S., Chilcot, J., & McBride, E. (2021). Psychological Distress in Women Living with Polycystic Ovary Syndrome: The Role of Illness Perceptions. Women’s Health Issues, 31(2). https://doi.org/10.1016/j.whi.2020.11.003
Mahata, S. K., & Corti, A. (2019). Chromogranin a and its fragments in cardiovascular, immunometabolic, and cancer regulation. In Annals of the New York Academy of Sciences (Vol. 1455, Issue 1). https://doi.org/10.1111/nyas.14249
Moldovan, G. E., Miele, L., & Fazleabas, A. T. (2021). Notch signaling in reproduction. In Trends in Endocrinology and Metabolism (Vol. 32, Issue 12). https://doi.org/10.1016/j.tem.2021.08.002
Mondal, S., Adhikari, N., Banerjee, S., Amin, S. A., & Jha, T. (2020). Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview. In European Journal of Medicinal Chemistry (Vol. 194). https://doi.org/10.1016/j.ejmech.2020.112260
Murata, H., Tanaka, S., & Okada, H. (2022). The Regulators of Human Endometrial Stromal Cell Decidualization. In Biomolecules (Vol. 12, Issue 9). https://doi.org/10.3390/biom12091275
Neven, A. C. H., Laven, J., Teede, H. J., & Boyle, J. A. (2018). A summary on polycystic ovary syndrome: Diagnostic criteria, prevalence, clinical manifestations, and management according to the latest international guidelines. Seminars in Reproductive Medicine, 36(1). https://doi.org/10.1055/s-0038-1668085
Poulsen, S. B., & Fenton, R. A. (2019). K+ and the renin–angiotensin–aldosterone system: new insights into their role in blood pressure control and hypertension treatment. In Journal of Physiology (Vol. 597, Issue 17). https://doi.org/10.1113/JP276844
Rodriguez Paris, V., & Bertoldo, M. J. (2019). The Mechanism of Androgen Actions in PCOS Etiology. In Medical sciences (Basel, Switzerland) (Vol. 7, Issue 9). https://doi.org/10.3390/medsci7090089
Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y. (2022). Inflammation in obesity, diabetes, and related disorders. In Immunity (Vol. 55, Issue 1). https://doi.org/10.1016/j.immuni.2021.12.013
Rostamtabar, M., Esmaeilzadeh, S., Tourani, M., Rahmani, A., Baee, M., Shirafkan, F., Saleki, K., Mirzababayi, S. S., Ebrahimpour, S., & Nouri, H. R. (2021). Pathophysiological roles of chronic low-grade inflammation mediators in polycystic ovary syndrome. In Journal of Cellular Physiology (Vol. 236, Issue 2). https://doi.org/10.1002/jcp.29912
Sabir, S., Akash, M. S. H., Fiayyaz, F., Saleem, U., Mehmood, M. H., & Rehman, K. (2019). Role of cadmium and arsenic as endocrine disruptors in the metabolism of carbohydrates: Inserting the association into perspectives. In Biomedicine and Pharmacotherapy (Vol. 114). https://doi.org/10.1016/j.biopha.2019.108802
Sanchez-Garrido, M. A., & Tena-Sempere, M. (2020). Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies. In Molecular Metabolism (Vol. 35). https://doi.org/10.1016/j.molmet.2020.01.001
Schumacher, N., & Rose-John, S. (2019). Adam17 activity and il-6 trans-signaling in inflammation and cancer. In Cancers (Vol. 11, Issue 11). https://doi.org/10.3390/cancers11111736
Schumacher, N., & Rose-John, S. (2022). ADAM17 orchestrates Interleukin-6, TNFα and EGF-R signaling in inflammation and cancer. Biochimica et Biophysica Acta - Molecular Cell Research, 1869(1). https://doi.org/10.1016/j.bbamcr.2021.119141
Simionescu, G., Doroftei, B., Maftei, R., Obreja, B.-E., Anton, E., Grab, D., Ilea, C., & Anton, C. (2021). The complex relationship between infertility and psychological distress (Review). Experimental and Therapeutic Medicine, 21(4). https://doi.org/10.3892/etm.2021.9737
Sisto, M., Ribatti, D., & Lisi, S. (2021). Organ fibrosis and autoimmunity: The role of inflammation in TGFβ‐dependent EMT. In Biomolecules (Vol. 11, Issue 2). https://doi.org/10.3390/biom11020310
Taghipour, Y. D., Hajialyani, M., Naseri, R., Hesari, M., Mohammadi, P., Stefanucci, A., Mollica, A., Farzaei, M. H., & Abdollahi, M. (2019). Nanoformulations of natural products for management of metabolic syndrome. In International Journal of Nanomedicine (Vol. 14). https://doi.org/10.2147/IJN.S213831
Witchel, S. F., Oberfield, S. E., & Peña, A. S. (2019). Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment with Emphasis on Adolescent Girls. In Journal of the Endocrine Society (Vol. 3, Issue 8). https://doi.org/10.1210/js.2019-00078
Xue, F., Cheng, J., Liu, Y., Cheng, C., Zhang, M., Sui, W., Chen, W., Hao, P., Zhang, Y., & Zhang, C. (2022). Cardiomyocyte-specific knockout of ADAM17 ameliorates left ventricular remodeling and function in diabetic cardiomyopathy of mice. Signal Transduction and Targeted Therapy, 7(1). https://doi.org/10.1038/s41392-022-01054-3
Zehravi, M., Maqbool, M., & Ara, I. (2021). Polycystic ovary syndrome and reproductive health of women: A curious association. In International Journal of Adolescent Medicine and Health (Vol. 33, Issue 6). https://doi.org/10.1515/ijamh-2021-0031
Zeng, X., Xie, Y. jie, Liu, Y. ting, Long, S. lian, & Mo, Z. cheng. (2020). Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance and obesity. In Clinica Chimica Acta (Vol. 502). https://doi.org/10.1016/j.cca.2019.11.003
Zhao, H., Zhang, J., Cheng, X., Nie, X., & He, B. (2023). Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment. In Journal of Ovarian Research (Vol. 16, Issue 1). https://doi.org/10.1186/s13048-022-01091-0
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Boren Preap, Kimsor Hong, Jianlin Chen, Jingfei Chen

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-ShareAlike that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).