The Effect of Magnesium Sulfate on Contraction of Pregnant Women with Cases of Partus Premature Imminent in District General Hospitals Mentawai Islands
DOI:
https://doi.org/10.59653/ijmars.v2i02.758Keywords:
magnesium sulfate, premature labour, pregnantAbstract
In 2020, it was recorded that the number of neonatal deaths in West Sumatra was 104, with 18 cases being the cause of prematurity, where the Mentawai Islands district had the highest ranking of neonate deaths with 44 deaths and 10 cases being the cause of prematurity. This research aims to determine the effect of administering magnesium sulfate therapy on contractions of pregnant women in cases of imminent premature labour at the Mentawai Islands District Hospital in 2021. This type of research is pre-experimental with a Grup Pretest-Post Test design because in this study a random sample was not carried out by taking samples from secondary data retrospectively. Data taken came from medical records of inpatients who had a diagnosis of premature labour (ICD Total sampling was taken with a total sample size of 48, and statistical data analysis using the McNemar test. Data from 48 research subjects experienced contractions and received magnesium sulfate therapy. During monitoring after administering magnesium sulfate, 3 subjects still experienced contractions and 45 subjects did not experience contractions. Uterine contractions occurred significantly more before magnesium sulfate therapy than after magnesium sulfate therapy (P<0.005). There is a significant relationship between administering magnesium sulfate to patients with preterm labour to stop uterine contractions at the Mentawai Islands District Hospital. Apart from being a tocolytic therapy, magnesium sulfate also has a neuroprotectant effect so it is highly recommended for therapy in cases of premature parturition.
Downloads
References
Abd El-Aziz, R. A. E. R., Asal, M. F., & Maaly, A. M. (2023). Effectiveness of adding magnesium sulfate to bupivacaine in ultrasound guided serratus anterior plane block in patients undergoing modified radical mastectomy. Egyptian Journal of Anaesthesia, 39(1). https://doi.org/10.1080/11101849.2023.2168856
American College of Obstetricians and Gynecologists (ACOG) 2016, Management of preterm labour, Practice Bulletin No. 159. Obstet Gynecol; 127:e29–38. https://journals.lww.com/greenjournal/Fulltext/2016/01000/Practice_Bulletin-No159__Management_of_Preterm.51.aspx
Arab, H. H., Khames, A., Alsufyani, S. E., El-Sheikh, A. A. K., & Gad, A. M. (2023). Targeting the Endoplasmic Reticulum Stress-Linked PERK/GRP78/CHOP Pathway with Magnesium Sulfate Attenuates Chronic-Restraint-Stress-Induced Depression-like Neuropathology in Rats. Pharmaceuticals, 16(2). https://doi.org/10.3390/ph16020300
Arrowsmith S, Neilson J, Wray S, 2016 The combination tocolytic effect of magnesium sulfate and an oxytocin receptor antagonist in myometrium from singleton and twin pregnancies, American Journal of Obstetrics and Gynecology, Volume 215, Issue 6, Pages 789.e1-789.e9, https://doi.org/10.1016/j.ajog.2016.08.015
Bear M, Bonnheim M, Gallardo C, Kruse, CM, Landers K, Lanzoni A, Lizardi R, Luckett M, Piacenza D, Psaros K, Rena G, Simpson C, Sundlie B, Wilsker D,2017, Nursing Key Topics Review: Maternity, Elsevier, Inc, Missouri
Cunningham FG, Leveno KJ, Dashe JS, Hoffman BL, Spong CY, Casey BM, 2022, Williams Obstetrics, 26th ed, Mc Graw Hill, New York.
Dahlan MS, 2010, Statistics For Medicine And Health, Salemba Medika, Jakarta
Gáspár, R and Tóth, JH 2013, Calcium Channel Blockers as Tocolytics: Principles of Their Actions, Adverse Effects and Therapeutic Combinations, Pharmaceuticals, 6,689-699, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816733/pdf/pharmaceuticals-06-00689.pdf
Herman S, Santoso B, Joewono HT, Sulistyono A, Basuki H, Miftahussurur M, 2020, Risk Factors as an Indicator of Non-Complications Spontaneous Preterm Birth: a Study in Eight Hospitals. Journal of International Dental and Medical Research. 13(1):395-399. https://scholar.unair.ac.id/en/publications/risk-factors-as-an-indicator-of-non-complications-spontaneous-pre
Indonesian Ministry of Health. Indonesia Health Profile 2020. Jakarta: Ministry of Health; 2020.
Indonesian Ministry of Health. Indonesia Health Profile 2021. Jakarta: Ministry of Health; 2021.
Laksmi, N. P. C. (2023). Relationship between Husband’s Social Support and Participation in Pregnant Women Class in Denpasar City in 2019. Journal of Health Science and Medical Therapy, 2(01), 63–69. https://doi.org/10.59653/jhsmt.v2i01.444
Lyell, D J, Pullen, K, Campbell, L, Ching, S, Druzin, ML, Chitkara, U, Burrs, D, Caughey, A B, El-Sayed, Yasser Y, Magnesium Sulfate Compared With Nifedipine for Acute Tocolysis of Preterm Labor: A Randomized Controlled Trial. Obstetrics & Gynecology: July 2007 - Volume 110 - Issue 1 - p 61-67 doi:10.1097/01.AOG.0000269048.06634.35
Magee L, Sawchuck D, Synnes A, Dadelszen P: Magnesium Sulfate for Fetal Neuroprotection, SOGC CLINICAL PRACTICE GUIDELINE| VOLUME 41, ISSUE 4, P505-522, APRIL 01, 2019 No. 376 https://www.jogc.com/article/S1701-2163(18)30760-6/fulltext
Manaf, N. (2023). Guiding the Behavior of Young Women in Family Planning and Prevention of Anemia through Peer Group Empowerment as an Effort to Prevent Stunting. Journal of Health Science and Medical Therapy, 1(01), 21–29. https://doi.org/10.59653/jhsmt.v1i01.143
Mega, T. A., Gugsa, H., Dejenie, H., Hussen, H., & Lulseged, K. (2023). Safety and Effectiveness of Magnesium Sulphate for Severe Acute Asthma Management Among Under-five Children: Systematic Review and Meta-analysis. In Journal of Asthma and Allergy (Vol. 16). https://doi.org/10.2147/JAA.S390389
Melchor Corcóstegui, I., Unibaso Rodríguez, E., Ruiz Blanco, N., Nikolova, T., Nikolova, N., Burgos San Cristóbal, J., & Melchor Marcos, J. C. (2023). Is mid-trimester cervical length screening effective for reduction of threatened preterm labor? Taiwanese Journal of Obstetrics and Gynecology, 62(3). https://doi.org/10.1016/j.tjog.2022.09.014
Miller, F. A., Sacco, A., David, A. L., & Boyle, A. K. (2023). Interventions for Infection and Inflammation-Induced Preterm Birth: a Preclinical Systematic Review. In Reproductive Sciences (Vol. 30, Issue 2). https://doi.org/10.1007/s43032-022-00934-x
Omori-Shimano, S., Tominaga, T., & Ikeda, K. (2023). Maternal magnesium sulfate administration increases early-onset hyperkalemia risk in premature infants: A propensity score-matched, case-control study. Pediatrics and Neonatology, 64(2). https://doi.org/10.1016/j.pedneo.2022.06.011
Peng, Q., Yang, X., Li, J., You, Y., & Zhao, X. chun. (2023). The Effect of the Magnesium Sulfate in Ultrasound-Guided Quadratus Lumborum Block on Postoperative Analgesia: A Randomized Controlled Trial. Pain and Therapy, 12(1). https://doi.org/10.1007/s40122-022-00436-3
POGI 2019, Preterm Labor Guide, Central Executive of the Indonesian Obstetrics and Gynecology Association, Jakarta
Prasad, P., Romero, R., Chaiworapongsa, T., Gomez-Lopez, N., Lo, A., Galaz, J., Taran, A. B., Jung, E., Gotsch, F., Than, N. G., & Tarca, A. L. (2023). Further Evidence that an Episode of Premature Labor Is a Pathologic State: Involvement of the Insulin-Like Growth Factor System. Fetal Diagnosis and Therapy, 50(4). https://doi.org/10.1159/000530862
Pratt, S. L., Bowen, M., & Redpath, A. (2023). Resolution of sustained ventricular tachycardia in a horse presenting with colic with magnesium sulfate. Equine Veterinary Education, 35(8). https://doi.org/10.1111/eve.13775
Suman, V and Luther, E 2022, Preterm Labor., StatPearls Publishing, https://www.ncbi.nlm.nih.gov/books/NBK536939/#article-27706.s1
Tissarinen, P., Tiensuu, H., Haapalainen, A. M., Määttä, T. A., Ojaniemi, M., Hallman, M., & Rämet, M. (2023). Elevated human placental heat shock protein 5 is associated with spontaneous preterm birth. Pediatric Research, 94(2). https://doi.org/10.1038/s41390-023-02501-9
Vanhaesebrouck, S., Zecic, A., Goossens, L., Keymeulen, A., Garabedian, L., De Meulemeester, J., Naessens, P., De Coen, K., & Smets, K. (2023). Association of antenatal magnesium sulfate with reduced late-onset sepsis in extreme preterm infants. Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine, 78(1). https://doi.org/10.1080/17843286.2022.2048531
Vinstrup, J., Bláfoss, R., López-Bueno, R., Calatayud, J., Villadsen, E., Clausen, T., Doménech-García, V., & Andersen, L. L. (2023). Pain Control Beliefs Predict Premature Withdrawal From the Labor Market in Workers With Persistent Pain: Prospective Cohort Study With 11-Year Register Follow-up. Journal of Pain, 24(10). https://doi.org/10.1016/j.jpain.2023.05.009
WHO, 2015. WHO Recommendations On Interventions To Improve Preterm Birth, WHO Press, Geneva
WHO 2018, Fact Sheet Preterm Birth, https://www.who.int/news-room/fact-sheets/detail/preterm-birth
Zhao, C., Wang, L., Chen, L., Wang, Q., & Kang, P. (2023). Effects of magnesium sulfate on periarticular infiltration analgesia in total knee arthroplasty: a prospective, double-blind, randomized controlled trial. Journal of Orthopaedic Surgery and Research, 18(1). https://doi.org/10.1186/s13018-023-03790-w
Downloads
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2024 Fafelia Rozyka, Silvie Permata, Thins Yona, Febby Herayono

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-ShareAlike that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).